William Andrew Wallace, the second of the roommates at Ryland Hall, was pledged to that group by Gaw, his roommate. He came from Gaw's home town, Stuart's Draft, where he was born on May 7, 1882. He did not graduate but transferred to the Medical College of Virginia for his M.D., on which campus he launched the Beta Chapter (now Virginia Commonwealth University), becoming its first member. By this act, Sigma Phi Epsilon's expansion began.

He left Medical Collage for an internship in the Boston Floating Hospital, which he left shortly for another internship in a hospital in Richmond. Later, in 1908, he located at Spartanburg, South Carolina, continuing in practice to become one of the best-known practitioners in the state, and a devoted Sig Ep until his death in 1929.